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J Mol Histol. 42(6):499-504. 2011. doi: 10.1007/s10735-011-9357-z

Dickkopf (Dkk)-3 and β-catenin expressions increased in the transition from normal oral mucosal to oral squamous cell carcinoma.

Fujii MKatase NLefeuvre MGunduz MBuery RRTamamura RTsujigiwa HNagatsuka H.


Dickkopf (Dkk)-3, an inhibitor of the Wnt/β-catenin pathway, is reported as a potential tumor suppressor gene in many cancers. To gain a better comprehension of the mechanisms involved in the carcinogenesis of oral squamous epithelium, protein expression and localization of Dkk-3 and β-catenin was investigated in normal epithelium, dysplasias and squamous cell carcinoma (SCC). An increase in β-catenin and Ki-67 expressions was observed from dysplasias to poorly differentiated SCC. Interestingly, an increase in Dkk-3 positive cells was also noted, which was correlated to the cancer progression step. A change in Dkk-3 localization during the transformation of normal oral epithelium to SCC was clearly observed. Dkk-3 was localized in the cell membrane in normal oral epithelium and in dysplasias, whereas that was localized in both cell membrane and cytoplasm in SCC. These results suggest that Dkk-3 is involved in the carcinogenesis of SCC with a distinct function from those in other cancers.





最初の論文でDKK3をHNSCCの発生と進展に関わる重要な遺伝子として同定した(Katase N et al. Oncol Res. 2008)。


上皮内癌→浸潤癌においてDKK3の発現が変化するかを検討した。①は独立した論文として発表した(Katase N et al. Oncol Lett. 2013)。

















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